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STAT3 AND PSTAT3

STAT3 (signal transducer and activator of transcription 3) is a transcription factor, a protein that controls transcription of information from DNA to messenger RNA and is a member of the seven strong STAT family. STAT3 and phospho STAT3 (PSTAT3) malfunction has been implicated in a number of cancers including breast cancer due to is early role in mammary development.

Research work is ongoing by our scientific collaborators in Professor Rob Clarke’s Laboratory at the University of Manchester on the role of SFX-01 and its inhibition of STAT3/PSTAT3 in relation to the development of resistance to certain first line chemotherapy agents